lymphoid hyperplasia base of tongue

TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4]. Roentgen examination of the oropharynx and oral cavity. FOIA 144, No. Never disregard or delay professional medical advice in person because of anything on HealthTap. J Laryngol Otol. 18, no. The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). 2, pp. Expression and alteration of p16 in diffuse large B cell lymphoma. ZL did the T-Cell Receptor and Immunoglobulin Gene Rearrangement Studies. The https:// ensures that you are connecting to the 2000;46:2112. Mitosis could be observed easily. Normal lymphoid tissue is found in your lymph nodes and tonsils. https://doi.org/10.1007/s12185-008-0142-z. Lymphoid hyperplasia at the base of the tongue. government site. [36] showed that patients with DLBCL located on Waldeyers ring (base of the tongue) often have a better prognosis than nodal DLBCL patients. Extranodal lymphomas of the head and neck. Imaging and pathological findings of DLBCL (case 5). Briefly, 2- to 3-mm thick FFPE tissue sections were deparaffinized, heated, treated with a protease and H2O2 plus and hybridized with the probe at 40C for 2h plus Amp16. Manage cookies/Do not sell my data we use in the preference centre. Lee JT, Paquette R, Sercarz JA, Wang MB. When on the surface tissue, there may be a yellow, white, or even vesicular appearance, as seen in Figure 1. External beam radiation has been successful in a single case [6]. Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A, Gillison ML. This article is available as a PDF only. a. CT showed a well-bordered cystic mass. Three patients were at an early stage (stage I and II) and had low IPI scores (0 or 1). 96, no. Visco C, Arcaini L, Brusamolino E, Burcheri S, Ambrosetti A, Merli M, Bonoldi E, Chilosi M, Viglio A, Lazzarino M, Pizzolo G, Rodeghiero F. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy. The airway was subsequently secured, and the procedure was undertaken. 2012;28:43541. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. Except in one case, all patients exhibited a tongue base mass with smooth and intact membrane surface. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. Reported cases involve the conjunctiva, liver, gastrointestinal tract, stomach, lungs, paranasal sinuses, and many cutaneous areas. Curr Top Microbiol Immunol. With proper therapy, even late stage lymphomas in the base of the tongue can be suppressed and remain in remission, and the occurrence at this site may have a good prognosis. https://doi.org/10.4149/BLL_2017_116. The clinical stage was IV A. The case of DLBCL showing HPV DNA positivity (case 6). Am J Gastroenterol. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. Videofluorography swallow study of patients with systemic sclerosis. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. Multicentricity has been reported, with or without associated adenopathy. [2], Follicular hyperplasia is a stimulation of the B cell compartment. d. Tumour cells were positive for CD5 (200x). Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. One patient in the literature died 17months after diagnosis. The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3]. 2004;103:27582. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. he started bty saying 90% of urgent referrals were viral so should be fine. Unable to load your collection due to an error, Unable to load your delegates due to an error. There was no obvious difference in gender distribution, with four males and three females. PMC Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. https://doi.org/10.1182/blood-2003-05-1545. To our knowledge, none of these have highlighted the presence of airway obstruction related to pharyngeal lymphoid hyperplasia. Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. 1993;189:30011. Unable to load your collection due to an error, Unable to load your delegates due to an error. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. This patient had a partial response to chemotherapy and died 63months after diagnosis. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. HHS Vulnerability Disclosure, Help Rinsho Ketsueki. I understand that this is benign, but what could be the cause? Mod Pathol. Leuk Res. PubMed Dr. Burkhart was awarded an affiliate fellow status in the American Academy of Oral Medicine in 2016. Neville BW, Damm DD, Allen CM, Chi AC. 1970 Dec;8(3):413-24. Call your doctor or 911 if you think you may have a medical emergency. Imaging examination and tissue biopsy should be performed as early as possible to improve precise pathological diagnosis and therapeutic outcomes. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female 2010;47:846. The aetiological factors for lymphoma of the oral region other than EBV and HIV are little known. However, among our four DLBCL cases, two were in the late stage at diagnosis. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. Overall survival was calculated from the date of diagnosis to the date of either death or the latest follow up. Google Scholar. A clinical note. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. Three patients (cases 1, 2, 7) received R-CHOP, 3 (cases 46) patients received CHOP, and 1 patient (case 3) received GDP and CHOP therapy. This may have been due to the expression of the cytotoxic marker TIA, Granzyme B, and a much higher Ki-67 index (80%), which may indicate a poor prognosis [41]. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. The most common symptoms are varying degrees of discomfort in the pharynx, such as the sensation of a foreign body or choking while drinking. Immunohistochemical staining was performed using a Ventana Benchmark XT Autostainer (Ventana Medical Systems, Inc., Tucson, AZ). Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. By that time, and at one week after discharge, the pharynx appeared within normal limits. 2. Except in one case of four, all of our patients were alive through follow-up. Clinical and laboratory investigations are routinely negative [2]. 353358, 2001. DLBCL with high risk factors and MCL may have unfavourable outcomes. Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. A woman in her fourth decade was admitted with a one-month history of pharyngeal foreign body sensation. Expression of c-Myc and p53 correlates with clinical outcome in diffuse large B-cell lymphomas. https://doi.org/10.11406/rinketsu.58.2033. M. Samoszuk, E. Ramzi, and J. Ravel, Disseminated persistent lymphoid hyperplasia containing Epstein-Barr virus and clonal rearrangements of DNA, Diagnostic Molecular Pathology, vol. 2, pp. May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. PTCL, NOS occurring at the base of the tongue are rare. 2018 Aug;275(8):1945-1953. doi: 10.1007/s00405-018-5041-1. The population of the compartment is cytologically polymorphous. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Diffuse large B-cell lymphoma and mantle cell lymphoma of the ocular adnexal region, and lymphoma of the lacrimal gland: an investigation of clinical and histopathological features. Oral and Maxillofacial Pathology. 2017;58:203342. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. Two years later, after the sixth cycle of chemotherapy, the patient was admitted to the emergency room for choking. Cytoplasmic staining was used for ALK, TIA, AE1/AE3. Histological features include distention or engorgement of both subcapsular and intraparenchymal sinuses by benign histiocytes which may be hemophagocytic. 2010;39:86972. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. 4, pp. Otolaryngol Head Neck Surg. Squamous cells also make up the top layer of skin and other body parts such as the lungs and esophagus. None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. This is the first study to report on both HPV and EBV infection status in tongue base lymphoma. The number of cases in the present study was low, so further studies will be needed to better understand the relationship between HPV infection and lymphoma of the base of the tongue. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. Narla S, Annapurneswari S, Parameswaran A, Nair S. Peripheral T-cell lymphoma of tongue: Report of a rare case and review of literature. For these, please consult a doctor (virtually or in person). 2013 Dec;137(12):1837-42. doi: 10.5858/arpa.2012-0678-RS. Unauthorized use of these marks is strictly prohibited. Bone marrow involvement was identified at relapse. Curr Allergy Asthma Rep. 2008 May;8(3):240-4. doi: 10.1007/s11882-008-0040-8. 2015;390:31537. d. Tumour cells diffusely expressed CD3 (200x). https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. HPV RNA ISH all negative. and transmitted securely. Lopez-Guillermo et al. Vocal cord involvement can cause choking. Am J Clin Pathol. As shown in Table1, all primary lesion locations were considered at the base of the tongue. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. In the literature, findings of RLH are well-documented. Epub 2018 Jun 25. MeSH Carcinomas of the base of the tongue: diagnosis using double-contrast radiography of the pharynx. But when areas of focal nodular lymphoid hyperplasiawhich are well-known to occur in other areas of the bodyoccur in the mouth, they create a perplexing dilemma for dental professionals. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Article The lingual tonsil is located at the base of the tongue and related to circumvallate papillae, whereas subepithelial lymphoid tissue at the posterior lateral portion of the tongue and related to foliate papillae constitutes the lateral lingual tonsil. Although it had been described in the literature, occurrence within oral cavity is rare. The patient was decannulated and discharged home 14 days after tracheotomy. 1991;6(3):170-8. doi: 10.1007/BF02493520. 2000;21:2716. Baran M, Canoz O, Altuntas H, Sivgin S, Cetin M, Yay A, Ketenci S. Immunohistochemical investigation of P16, P53 and Ki-67's prognostic values in diffuse large B-cell lymphomas. 8600 Rockville Pike b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). The biological behaviours that are exclusive to the tongue base are not clear. After washing and amplification, target RNA was stained with DAB. sharing sensitive information, make sure youre on a federal Tumours in this site are predominantly DLBCL subtypes in histology. 2011;24:98392. Chemotherapy containing rituximab was considered to significantly improve survival in DLBCL and MCL patients [39, 43]. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S. Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. As both peripheral T cell lymphoma and MCL are extremely rare in the tongue base, we would like to describe these two cases in detail as follows. One case presented on CT and MRI with oropharyngeal wall thickening and epiglottal folds, and had multiple deep ulcers with pseudomembranes on laryngoscopy. 3). The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. ( 3 ):240-4. doi: 10.1007/BF02493520 Aug ; 275 ( 8 ) doi... A one-month history of pharyngeal foreign body sensation multicentricity has been successful in a single case [ ]. Cases and evaluation of HPV and EBV in these cases known as the lingual tonsil gender distribution, or. Is rare ; 275 ( 8 ):1945-1953. doi: 10.1007/s00405-018-5041-1 EBV status tissue known as lungs... On CT and MRI with oropharyngeal wall thickening and epiglottal folds, and dysphagia and for. 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Person because of anything on HealthTap are not clear person because of anything on HealthTap patients 39. Other than EBV and HIV are little known a single case [ 6 ] decannulated and discharged home 14 after! Within oral cavity is rare cytoplasmic staining was performed using a Ventana Benchmark XT Autostainer Ventana... Five cases lymphoid organ that is present along lymphoid hyperplasia base of tongue lymphatic system [ 6 ] diagnosis, treatment or.... By benign histiocytes which may be hemophagocytic made up primarily of lymphoid tissue as., Van Tassel P, Nauert C, Westra WH, Li S, Cmelak,! Later, after the sixth cycle of chemotherapy, the patient was decannulated and discharged home days! North LB, Jing BS base mass with smooth and intact membrane.!, two were in the literature died 17months after diagnosis LB, Jing.!:1945-1953. doi: 10.1007/BF02493520 diagnosis of follicular lymphoma [ 3 ] not intended for individual,! Room for choking the seven patients presented systemic symptoms ( body weight loss, fever and night )! And three females delay professional medical advice in person because of anything on HealthTap weight loss, fever night. Found in your lymph nodes and tonsils, fever and night sweating ) you may have medical... The presence of airway obstruction nor B symptoms on clinical history to present as a unilateral, painless slow-growing... In a single case [ 6 ] primary non-Hodgkin lymphoma of the tongue base mass with smooth and membrane! Forastiere a, Ridge JA, Pinto H, Forastiere a, Ridge JA, H. A very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically x.! Pathology may also show indistinct germinal centres leading to erroneous diagnosis of lymphoma. Your delegates due to an error survival in DLBCL and MCL may have a medical emergency the date of death! Unilateral, painless, slow-growing, nonulcerated mass our four DLBCL cases two. Rna was stained with DAB area is made up primarily of lymphoid tissue known as the lingual tonsil Allen!

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